Design and synthesis
of two new immunosuppressants
Since ages people have been suffering from different immune system disorders.
Oversensitivity of the immune system can lead to allergies and in peculiar
cases to autoimmune diseases, like multiple sclerosis, juvenile diabetes
and rheumatoid joint inflammation. In modern times when organ transplantations
may save human life appeared new problem connected with immune response
against transplants, rejection. Efficient way of curing such symptoms
is therapy based on immunosuppressive drugs, but drugs used currently
cause a lot of side effects. It creates needs for new immunosuppressants.
Previous studies proved that some fragments of the proteins essential
for immune system can modulate immunity. Lukasz and Mariusz Jaremko on
the basis of the knowledge about the shortest biological active fragment
of ubiquitin protein designed two new peptides. These compounds can be
used to explain why partial sequences of ubiquitin are able to lover
the activity of the immune system. This knowledge could be applied in
diagnostics of some immune diseases and design of more efficient drugs
giving hope to people who suffer from some immune disorders. Brothers
synthesized and purificated designed peptides, which will be tested for
the biological properties.